Microsoft MAI-DxO: Can You Try It?
MAI Diagnostic Orchestrator — status as of October 2026
MAI-DxO (Microsoft AI Diagnostic Orchestrator) is a research system from Microsoft AI that makes several AI models act like a virtual panel of doctors, ordering questions and tests one step at a time. Microsoft announced it in June 2025 and calls it a research demonstration: there is no MAI-DxO product, API or download, and it is not approved for clinical use.
- Developer
- Microsoft AI
- Public access
- Not available (research demonstration)
- What it is
- Orchestrator on top of existing LLMs
- Paper
- arXiv preprint, June 2025
Try a step-by-step medical AI chat
MAI-DxO is not open to the public. Dr7's medical AI chat below is a different system: describe a case or your symptoms and it reasons through possible diagnoses step by step. For education only — not a substitute for a doctor.
Dr7.ai Medical AI Chat
Free demo · not MAI-DxO
Have a lab report, X-ray or photo of a symptom? Upload it in the full AI diagnosis tool.
Upload for AI analysisGo beyond the free demo
Upgrade to Pro for image analysis, full AI diagnostic reports and higher daily limits — or start with a free AI analysis of your medical image.
Can you use MAI-DxO? How to access it
No. Microsoft says MAI-DxO and its benchmark, SDBench, are research demonstrations only and are not available as a public orchestrator or benchmark. There is no app, API, open-source release or waitlist.
- MAI-DxO is not a new AI model. It is an orchestration method that directs existing language models — the paper tested families from OpenAI, Google, Anthropic, xAI, Meta and DeepSeek — through a structured diagnostic process.
- Microsoft states the work is not yet approved for clinical use and still needs safety testing, clinical validation and regulatory review.
- Copilot Health, which Microsoft announced for US adults in March 2026, is a separate consumer product. Microsoft says it is not intended to diagnose diseases.
- Community projects that re-implement the idea from the paper are not Microsoft's MAI-DxO.
What you can use instead today
Dr7 medical AI chat
Free on this page — describe symptoms and get step-by-step reasoning about possible causes.
Open AI diagnosisMedGemma
Google's open-weight medical models, available to download from Hugging Face.
Explore MedGemmaKey MAI-DxO results
Sequential Diagnosis Benchmark (SDBench): 304 NEJM clinicopathological cases turned into step-by-step diagnostic encounters
| Setup | Diagnostic accuracy | Cost per case | Source |
|---|---|---|---|
| MAI-DxO, ensemble configuration (with OpenAI o3) | 85.5% | $7,184 | arXiv 2506.22405 |
| MAI-DxO, no budget limit | 81.9% | $4,735 | arXiv 2506.22405 |
| 21 practicing physicians (US & UK, median 12 years' experience) | 20% on average | $2,963 | arXiv 2506.22405 |
Costs are simulated test costs. Physicians were asked not to use search engines, AI tools or other online sources, and the cases are rare, complex NEJM teaching cases — not everyday practice. The results come from an arXiv preprint.
MAI-DxO timeline
Late 2024
Microsoft AI forms a consumer health team of clinicians, engineers and AI scientists.
Jun 2025
Microsoft announces MAI-DxO and SDBench in "The Path to Medical Superintelligence" and posts the preprint "Sequential Diagnosis with Language Models".
Mar 2026
Microsoft announces Copilot Health for US adults, a separate consumer product that is not intended to diagnose. MAI-DxO remains a research system.
Oct 2026
Microsoft has not announced a public release, API or product for MAI-DxO.
MAI-DxO FAQ
Short, sourced answers
Is MAI-DxO available to the public?
No. Microsoft describes MAI-DxO as a research demonstration that is not available as a public orchestrator, and says it is not yet approved for clinical use.
What does MAI-DxO stand for?
MAI-DxO stands for Microsoft AI Diagnostic Orchestrator. "MAI" is Microsoft AI, the company's AI division, and "DxO" means diagnostic orchestrator.
How does MAI-DxO work?
A language model plays five roles of a virtual medical panel — Dr. Hypothesis, Dr. Test-Chooser, Dr. Challenger, Dr. Stewardship and Dr. Checklist — that keep a list of possible diagnoses, choose the next test, challenge premature conclusions and watch costs. It asks questions and orders tests step by step instead of seeing the whole case at once.
How accurate is MAI-DxO?
On 304 NEJM cases, MAI-DxO with OpenAI's o3 reached 85.5% accuracy in its best (ensemble) configuration, versus an average of 20% for 21 experienced physicians who worked without search engines or AI tools. These are preprint results on rare teaching cases.
Is MAI-DxO part of Copilot?
No. Copilot Health, announced in March 2026, is a separate consumer product, and Microsoft says it is not intended to diagnose. Microsoft has not announced MAI-DxO in Copilot or any other product.
Is Dr7.ai affiliated with Microsoft?
No. Dr7.ai is independent and is not affiliated with Microsoft. The chat on this page does not run MAI-DxO; it is Dr7's own medical AI assistant, for educational use only.
Sources
- Microsoft AI: The Path to Medical Superintelligence (June 2025)
- arXiv 2506.22405: Sequential Diagnosis with Language Models
- Microsoft AI: Introducing Copilot Health (March 2026)
Dr7.ai is not affiliated with Microsoft. MAI-DxO is a Microsoft research system; the name is used only to describe it. Information is current as of October 2026. Dr7's AI chat is for education only and is not a substitute for professional medical advice.